Lab De Baere Research

Check out what we do!
  • rare disease
  • human genetics
  • multi-omics
  • statistical methodology
  • modeling with stem cells
Inherited retinal diseases (IRD) cause early-onset blindness, impacting over two million individuals globally. These monogenic disorders exhibit significant clinical and genetic heterogeneity, with over 260 identified disease genes. 
Genetic developmental disorders typically result from coding genome variants, leading to conditions such as infertility and intersex traits. Precise expression of development-related genes is critical and governed by the regulatory genome, which remains not yet fully understood.

Inherited Retinal Diseases

​An Integrated CRIPR/iPSC-based approach to elucidate RPE65's uncertain variants, a target for gene therapy

Eline Van Vooren, PhD Candidate
Eline Geens, PhD Candidate

Role of the ultraconserved IRXA cluster in North Carolina Macular Dystrophy, a retinal enhanceropathy

Lieselot Vincke, PhD Candidate

Mapping of 3D genome topologies in human retina, RPE, PPCs and ROs

Nelson Martins, PhD Candidate
Inherited retinal diseases (IRD) cause early-onset blindness, impacting over two million individuals globally. These monogenic disorders exhibit significant clinical and genetic heterogeneity, with over 260 identified disease genes. 
In this multidisciplinary field we currently focus on genomics, proteomics, epigenomics, transcriptomics and how to integrate these data. By generating vast amounts of data, OMICS technologies provide detailed insights into the molecular mechanisms of health and disease.
Genetic developmental disorders typically result from coding genome variants, leading to conditions such as infertility and intersex traits. Precise expression of development-related genes is critical and governed by the regulatory genome, which remains not yet fully understood.
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