DE BAERE LAB
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​De Baere Lab

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About our research

Our group focuses on the driving genetic factors behind rare and developmental disorders. Our current research can be divided two major compartments: ​ Inherited Retinal Disease and Gonadal Developmental genetics. We  have active projects on RPE65-associated IRD, North-Carolina Macular Dystrophy, targeted gene therapy for IRD, Blepharophimosis syndrome and Disorders of Sex Development. We leave no stone unturned and use state-of-the-art laboratory techniques to investigate at both the genomic (single nucleotide variations, structural variants and copy number variations) and the epigenomic (regulatory elements, non-coding RNAs and epigenetic modifications) level. For functional analyses we use commercially available cell lines, iPSC-derived cell lines, patient-derived cells as well as frog in vivo models (Xenopus tropicalis). It is our hope that by mapping the complex (epi-)genetic landscape of rare diseases as thoroughly as possible, future patients can enjoy better treatment options and a better quality of life.
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De Baere Lab © 2025
  • Home
  • News
  • Research
    • IRD
    • Gonads
    • Omics
  • Team
  • Publications
  • Alumni
  • CONTACT