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New paper on comparative 3d genome analysis in the retina

22/6/2023

 
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NEW PAPER ALERT!

​By Dr. Eva D'haene & Victor Lopez Soriano

Through extensive comparative 3D genome mapping, based on genome-wide (Hi-C), promoter-centric (HiChIP) and locus-specific (UMI-4C) assays of human neural retina and RPE, we have shown that gene regulation at key IRD loci is likely mediated by tissue-specific chromatin interactions. These findings do not only provide insight into tissue-specific regulatory landscapes of IRD genes, but also delineate the search space for non-coding genomic variation underlying unsolved IRD.
NEW PAPER

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